Autosomal dominant inheritance pattern Huntingtons disease is caused by an inherited defect in a single gene. Huntingtons disease is an autosomal dominant disorder, which means that a person needs only one copy of the defective gene to develop the disorder.
How does Huntingtons disease passed through families?
Huntington disease (HD) is inherited in an autosomal dominant manner. This means that having a change ( mutation ) in only one of the 2 copies of the HTT gene is enough to cause the condition. When a person with HD has children, each child has a 50% (1 in 2) chance to inherit the mutated gene and develop the condition.
Can you get Huntingtons disease if neither of your parents have it?
It would be very unlikely indeed that you have HD if neither your parents nor grandparents have it. This is because almost all individuals with HD have inherited the gene from a parent who also has symptoms of HD.
Is Huntingtons disease passed from mother or father?
There have been reports that juvenile onset Huntingtons chorea is almost always inherited from the father, and that late-onset Huntingtons chorea is inherited more often from the mother than from the father.